Abstract Background Multi-omics data can provide a stereoscopic view to explore potential causal variations and genes, as well as underlying genetic mechanisms of complex traits.However, for many non-mammalian species, including chickens, these resources are poorly integrated and reused, greatly limiting genetic research and breeding processes of t
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs.Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field a
Model Driven Engineering (MDE) is an emerging approach of software engineering.MDE Clothing emphasizes the construction of models from which the implementation should be derived by applying model transformations.The Ontology Definition Meta-model (ODM) has been proposed as a profile for UML models of the Web Ontology Language (OWL).In this context,
Background.There are many patient decision aids (DAs) available, yet there is limited evidence on comparative effectiveness of different tools.Objective.To examine feasibility of a study protocol and gather preliminary data on comparative effectiveness.Methods.Adult patients seeing a surgeon to discuss treatment for hip or knee osteoarthritis were
Pervasive political corruption has brought the first Italian republic (1946-94) to its bitter end.The transition from the first to the second republic will be achieved with a mixed system based for 3/4 on constituencies where parliament members are elected by plurality rule and for 1/4 with a proportional system.According to the opinion polls made